Monte Carlo simulation for dosage optimization of the best available therapy for bloodstream infections secondary to carbapenemase-producing Klebsiella pneumoniae in critically ill patients

Monte Carlo simulation for dosage optimization of the best available therapy for bloodstream infections secondary to carbapenemase-producing Klebsiella pneumoniae in critically ill patients

Objective: We aimed to use Monte Carlo simulation, based on pharmacokinetic/pharmacodynamic targets, to investigate and determine the optimal dosage of the available combination therapies for carbapenem-resistant Klebsiella pneumoniae (CRKP) in critically ill patients. Methods: We collected CRKP cli...

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Bibliographic Details
Main Authors: Sujareenoot Suya, Worapong Nasomsong, Wichai Santimaleeworagun, Piraporn Juntanawiwat, Tassananwan Chatreewonanakul, Weerayuth Saelim
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Carbapenem-resistant enterobacterales
Metallo-beta-lactamase
Oxacillinases
Tigecycline
Colistin
Aminoglycoside
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524004417
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