Targeted expansion of cytotoxic T cells using IL-12 and CD137L supplementation enhances antitumor efficacy

The increasing success of allogenic Vδ2 T cell immunotherapy for the treatment of cancer has been demonstrated in recent studies. Vδ2 T cells recognize phosphoantigens, intermediates of the mevalonate pathway, through butyrophilin molecules, and they are not major histocompatibility complex (MHC) re...

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Bibliographic Details
Main Authors: Marta Sanz, Brendan T. Mann, Elyse K. McMahon, Alberto Bosque, Samuel Simmens, Natalia Soriano-Sarabia
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Oncology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000657
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