Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.

Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.

Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory stereocilia and convey force to yet unidentified transduction channels. Current models postulate a static composition of the tip link, with protocadherin 15 (PCDH15) at the lower and cadherin 23 (CDH23) at th...

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Main Authors: Artur A Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Kateri J Spinelli, Zubair M Ahmed, Inna A Belyantseva, Thomas B Friedman, Peter G Barr-Gillespie, Gregory I Frolenkov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1001583
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https://doi.org/10.1371/journal.pbio.1001583

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