Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates gut microbiota (GM) to improv...

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Bibliographic Details
Main Authors: Yaojun Rong, Guiyu Zhang, Wenhao Ye, Linhua Qi, Xiaojiang Hao, Xiaolin Li, Wuhong Zhang, Yangfa Chao, Shaodong Gu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Cancer Medicine
Subjects:
16S rRNA sequencing
colorectal cancer
gut microbiota
liquid chromatography–mass spectrometry (LC–MS)
network pharmacology
Shaoyao decoction
Online Access:https://doi.org/10.1002/cam4.70813
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https://doi.org/10.1002/cam4.70813

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