Approach to Pregnancy Affected by Kell Alloimmunization
Hemolytic disease of the fetus and newborn (HDFN) is the development of anemia, hyperbilirubinemia, and finally hydrops fetalis in the fetus when antibodies to antigens on the surface of erythrocytes are transferred from the placenta to the fetus. The most common cause is D-HDFN. K (KEL1) from the K...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2024/1929147 |
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| author | Serdar Aykut Suleyman Cansun Demir Ismaıl Cuneyt Evruke Mete Sucu Fatma Islek Uzay Mesut Avan Ozge Keles Bayer Emre Yalcin |
| author_facet | Serdar Aykut Suleyman Cansun Demir Ismaıl Cuneyt Evruke Mete Sucu Fatma Islek Uzay Mesut Avan Ozge Keles Bayer Emre Yalcin |
| author_sort | Serdar Aykut |
| collection | DOAJ |
| description | Hemolytic disease of the fetus and newborn (HDFN) is the development of anemia, hyperbilirubinemia, and finally hydrops fetalis in the fetus when antibodies to antigens on the surface of erythrocytes are transferred from the placenta to the fetus. The most common cause is D-HDFN. K (KEL1) from the Kell blood group system is the most potent immunogenic antigen after D among all blood group antigens. K-HDFN occurs in 0.1–0.3% of pregnant women. It accounts for 10% of cases of antibody-mediated severe fetal anemia. We present a successful management of Kell alloimmunization in a pregnant woman who had 3 times pregnancy loss with hydrops fetalis due to K-HDFN and who was proven to have K-HDFN in the postnatal period in her last pregnancy. |
| format | Article |
| id | doaj-art-dcc9b735ed114091869d6324c3b46587 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-dcc9b735ed114091869d6324c3b465872025-02-03T07:23:37ZengWileyCase Reports in Hematology2090-65792024-01-01202410.1155/2024/1929147Approach to Pregnancy Affected by Kell AlloimmunizationSerdar Aykut0Suleyman Cansun Demir1Ismaıl Cuneyt Evruke2Mete Sucu3Fatma Islek Uzay4Mesut Avan5Ozge Keles Bayer6Emre Yalcin7Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyHemolytic disease of the fetus and newborn (HDFN) is the development of anemia, hyperbilirubinemia, and finally hydrops fetalis in the fetus when antibodies to antigens on the surface of erythrocytes are transferred from the placenta to the fetus. The most common cause is D-HDFN. K (KEL1) from the Kell blood group system is the most potent immunogenic antigen after D among all blood group antigens. K-HDFN occurs in 0.1–0.3% of pregnant women. It accounts for 10% of cases of antibody-mediated severe fetal anemia. We present a successful management of Kell alloimmunization in a pregnant woman who had 3 times pregnancy loss with hydrops fetalis due to K-HDFN and who was proven to have K-HDFN in the postnatal period in her last pregnancy.http://dx.doi.org/10.1155/2024/1929147 |
| spellingShingle | Serdar Aykut Suleyman Cansun Demir Ismaıl Cuneyt Evruke Mete Sucu Fatma Islek Uzay Mesut Avan Ozge Keles Bayer Emre Yalcin Approach to Pregnancy Affected by Kell Alloimmunization Case Reports in Hematology |
| title | Approach to Pregnancy Affected by Kell Alloimmunization |
| title_full | Approach to Pregnancy Affected by Kell Alloimmunization |
| title_fullStr | Approach to Pregnancy Affected by Kell Alloimmunization |
| title_full_unstemmed | Approach to Pregnancy Affected by Kell Alloimmunization |
| title_short | Approach to Pregnancy Affected by Kell Alloimmunization |
| title_sort | approach to pregnancy affected by kell alloimmunization |
| url | http://dx.doi.org/10.1155/2024/1929147 |
| work_keys_str_mv | AT serdaraykut approachtopregnancyaffectedbykellalloimmunization AT suleymancansundemir approachtopregnancyaffectedbykellalloimmunization AT ismaılcuneytevruke approachtopregnancyaffectedbykellalloimmunization AT metesucu approachtopregnancyaffectedbykellalloimmunization AT fatmaislekuzay approachtopregnancyaffectedbykellalloimmunization AT mesutavan approachtopregnancyaffectedbykellalloimmunization AT ozgekelesbayer approachtopregnancyaffectedbykellalloimmunization AT emreyalcin approachtopregnancyaffectedbykellalloimmunization |