Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis

Inflammation-driven periostin in ECRS has contrasting effects on tissue structural integrity and osteitis

IntroductionEosinophilic chronic rhinosinusitis (ECRS) is a severe form of chronic rhinosinusitis characterized by type 2 inflammation, tissue remodeling, and bone thickening, known as osteitis. Periostin, a matricellular protein involved in extracellular matrix (ECM) regulation and T helper 2 (Th2)...

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Main Authors: Soo-In Kim, Min-Seok Rha, Jinsun Kim, Sang Hyeon Ahn, Ji-Hwan Ryu, Hyung-Ju Cho, Chang-Hoon Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
periostin
Th2 inflammation
eosinophilic chronic rhinosinusitis
osteitis
tissue remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596746/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596746/full

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