Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway

Introduction: Diarrhea is the primary dose-limiting side effect of capecitabine(Cap) hindering its clinical application, but the mechanism is unclear. Clarifying this mechanism may enhance the patient compliance and improve the treatment outcome. Objectives: To assess if the endogenous metabolic pro...

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Bibliographic Details
Main Authors: Zhipeng Wang, Zhijun Liu, Lili Cui, Jianguo Sun, Chen Bu, Mao Tang, Mingming Li, Shouhong Gao, Wansheng Chen, Xia Tao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Advanced Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003035
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