Building a potent TREM2 agonistic, biparatopic, common light chain antibody

Building a potent TREM2 agonistic, biparatopic, common light chain antibody

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays an important role in microglial function and has been genetically linked to Alzheimer’s disease. Activation of TREM2 signaling may contribute to protection against neurotoxic effects of amyloid. Numerous TREM2 activating antibodies have...

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Main Authors: Ana da Silva Almeida, Melissa L. Geddie, Anil Bhate, Chao Quan, Joseph W. Arndt, Yang Jiao, Joseph C. Santoro, Liron Noiman, Ramya Vijayakumar, Jorge Sanchez-Salazar, Abhishek Datta, Giovanna Antognetti, Ciputra Adijaya Hartana, Xue Fan Wang, Benjamin A. Smith, Dan Bartlett, Danté Duncan, Chia-Chen Liu, Karel Otero Gutierrez, Thomas O. Cameron, Samir Koirala, Heather A. Cooke
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Alzheimer’s disease
TREM2
biparatopic antibodies
bispecific antibodies
Agonistic antibodies
common light chain
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2546554
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2546554

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