Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis

Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent clinical syndrome with high morbidity and mortality. Although HFpEF frequently coexists with cardiometabolic diseases, the causal mechanisms and potential mediators remain poorly understood. Objec...

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Bibliographic Details
Main Authors: Mingzhi Lin, Jiuqi Guo, Hongqian Tao, Zhilin Gu, Wenyi Tang, Fuliang Zhou, Yanling Jiang, Ruyi Zhang, Dalin Jia, Yingxian Sun, Pengyu Jia
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cardiovascular Diabetology
Subjects:
HFpEF
Cardiometabolic diseases
Circulating mediators
Type 2 diabetes
IL1R1
Online Access:https://doi.org/10.1186/s12933-025-02738-0
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https://doi.org/10.1186/s12933-025-02738-0

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