Metabolic, transcriptomic, and proteomic adaptations in pancreatic ductal adenocarcinoma-patient derived xenograft models across serial passages

Metabolic, transcriptomic, and proteomic adaptations in pancreatic ductal adenocarcinoma-patient derived xenograft models across serial passages

Abstract Background Patient-derived xenograft (PDX) models are crucial for tumor biology and therapeutic response evaluations. The metabolic, transcriptomic, and proteomic changes in PDX models derived from pancreatic ductal adenocarcinoma (PDAC) during serial passaging remain poorly understood. Met...

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Bibliographic Details
Main Authors: Pengfei Guo, Haizong Fang, Han Shi, Junrong Zhang, Ge Song, Chongjiu Fan, Xinyu Qiu, Xianchao Lin, Shi Wen, Jianghua Feng, Heguang Huang, Tianhong Teng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Pancreatic ductal adenocarcinoma
Patient-derived xenograft models
Serial passaging
Tumor microenvironment
Multi-omics analysis
Online Access:https://doi.org/10.1186/s12967-025-06787-7
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https://doi.org/10.1186/s12967-025-06787-7

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