ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia

ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia

Abstract The study aimed to investigate the role of ELABELA (ELA) in early-onset preeclampsia (EOPE), a condition characterized by dysregulated trophoblast invasivity leading to inadequate remodeling of uterine spiral arteries and shallow placental implantation. Using immunohistochemical staining, q...

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Bibliographic Details
Main Authors: Lijing Wang, Xue Wang, Ningning He, Lin Yang, Yang Zou, Zhanping Weng, Li Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Preeclampsia
Placenta
Invasion
MEK
ERK
Online Access:https://doi.org/10.1038/s41598-025-15533-4
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https://doi.org/10.1038/s41598-025-15533-4

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