TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome
Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiolo...
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| Main Authors: | Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
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| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70384 |
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