TcMAC21 mouse model recapitulates abnormal vascular physiology observed in humans with Down syndrome

Abstract People with Down syndrome (DS) have abnormal vascular physiology, demonstrated by low systolic blood pressure (BP) and low aortic stiffness that are accompanied by endothelial dysfunction. The TcMAC21 mouse model of DS has many features observed in people with DS, although vascular physiolo...

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Bibliographic Details
Main Authors: Xiangyu Zheng, Mostafa Sabouri, Bryan J. Irwin, Joseph Bernardo, Daniel R. Machin
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.70384
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