Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold

Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold

Several new amino-substituted aza-acridine derivatives bearing one or two basic side chains have been designed and synthesized. Their anticancer activities were evaluated in vitro against two human cancer cell lines: T24 (urothelial bladder carcinoma, malignancy grade III) and WM266-4 (metastatic me...

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Bibliographic Details
Main Authors: Maria Karelou, Anthi Panara, Eleftheria Chatziorfanou, Aikaterini F. Giannopoulou, Dimitrios J. Stravopodis, Evagelos Gikas, Ioannis K. Kostakis
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
acridines
cancer
computational chemistry
cytotoxic assay
drug discovery
mass spectrometry
Online Access:https://www.mdpi.com/1420-3049/30/12/2612
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