Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer

Targeting LINC02544/miR-497-5p/CAPRIN1 axis via exosome-based siRNA to overcome immunotherapy resistance in triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, leading to poor clinical outcomes and resistance to targeted therapies. Immunotherapy has shown limited succe...

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Bibliographic Details
Main Authors: Bin Lian, Jiayi Li, Shihui Tang, Ting Li, Jinping Li
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Medicine
Subjects:
Triple-negative breast cancer
LINC02544
MiR-497-5p
Immunotherapy resistance
Exosome-based SiRNA delivery
Online Access:https://doi.org/10.1186/s10020-025-01336-w
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https://doi.org/10.1186/s10020-025-01336-w

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