The F1F3 recombinant chimera induced higher vaccine efficacy than its independent F1 and F3 components against Leishmania (L.) infantum chagasi mice infection

The F1F3 recombinant chimera induced higher vaccine efficacy than its independent F1 and F3 components against Leishmania (L.) infantum chagasi mice infection

IntroductionVisceral leishmaniasis (VL) is a severe human vector-borne CD4-immunosuppressive disease that can be lethal if untreated soon after symptoms arise. No vaccine is available against human VL, and its chemotherapy is highly toxic and requires hospitalization. VL patients show substantially...

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Bibliographic Details
Main Authors: Daniele Crespo Gomes, Maria Paula Fonseca-Ribeiro, Marcus Vinicius Alves-Silva, Clarisa B. Palatnik-de-Sousa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Leishmania (L.) infantum chagasi
visceral leishmaniasis
nucleoside hydrolase NH36
F1F3 recombinant chimera
mixed or T-cell regulatory response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598755/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598755/full

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