Structure-guided screening identified bioactive phytoconstituents Hernandonine and Anolobine as potential inhibitors of dual specificity protein kinase CLK1

Abstract Neurodegenerative diseases such as Alzheimer’s disease (AD) are becoming a global health concern because of their progressive nature and the extent of the disability they cause to the affected individuals. Existing therapies for neurodegenerative diseases are primarily limited to symptomati...

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Bibliographic Details
Main Authors: Sumaiya Khan, Arunabh Choudhury, Taj Mohammad, Anas Shamsi, Md Imtaiyaz Hassan, Asimul Islam
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-97753-2
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