Evolving fitness and immune escape: a retrospective analysis of SARS-CoV-2 spike protein (2020-2024) using protein language model

Evolving fitness and immune escape: a retrospective analysis of SARS-CoV-2 spike protein (2020-2024) using protein language model

IntroductionThe COVID-19 pandemic posed global health challenges. Understanding SARS-CoV-2’s evolutionary dynamics, especially fitness and immune escape, is vital for public health. This study uses protein language models to assess how genetic variations affect viral adaptability and immunity.Method...

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Bibliographic Details
Main Authors: Sihua Peng, Leke Lyu, Ludy Registre Carmola, Sachin Subedi, M. H. M. Mubassir, Mohamed A. Bakheet, Justin Bahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
spike protein
protein language models
protein fitness
immune escape
retrospective analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576414/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576414/full

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