Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model

Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model

Summary: Individuals with Down syndrome (DS), caused by trisomy of chromosome 21 (chr21, T21), are strongly predisposed to Alzheimer’s disease (AD), due to triplication of the APP gene, with ∼100% penetrance of AD brain pathology by age 40 and variable onset of dementia thereafter. It remains unclea...

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Bibliographic Details
Main Authors: Paula Araya, Brian Niemeyer, Kyndal Schade, Lauren N. Dunn, Katherine Waugh, Nicolas Busquet, Connie Brindley, Chrisstopher Brown, Caitlin Winkler, Hannah R. Lyford, Eleanor C. Britton, Michael Ludwig, Julie Siegenthaler, Matthew D. Galbraith, Joaquin M. Espinosa, Kelly D. Sullivan
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Neuroscience
Behavioral neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225013914
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