Severe attenuation of circadian clock output in the heart following sustained augmentation of cardiomyocyte protein O-GlcNAcylation

Severe attenuation of circadian clock output in the heart following sustained augmentation of cardiomyocyte protein O-GlcNAcylation

BackgroundChanges in circadian-related behaviors (e.g., the timing of food intake, sleep cycles) and the environment (e.g., light-dark cycles) increase the risk of numerous cardiometabolic diseases, including diabetes mellitus and cardiac disease. Recent studies indicate a close interrelationship be...

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Main Authors: Gobinath Shanmugam, Samuel F. Chang, Helen E. Collins, Chae-Myeong Ha, Mariame S. Kane, Luke Potter, Lily Xie, Luyun Zou, Jianhua Zhang, John C. Chatham, Adam R. Wende, Martin E. Young
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
chronobiology
fibrosis
gene expression
post-translational modification
glycobiology
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1601407/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1601407/full

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