The Novel Long QT Syndrome Type 2-associated F129I Mutation in the KCNH2 Gene Significantly Affects IKr Through the hERG1 Homomeric and Heteromeric Potassium Channels

The Novel Long QT Syndrome Type 2-associated F129I Mutation in the KCNH2 Gene Significantly Affects IKr Through the hERG1 Homomeric and Heteromeric Potassium Channels

Objective:. The long QT syndrome type 2 is caused by the loss-of-function mutations in the KCNH2 gene, which encodes hERG1, the voltage-gated potassium channel. The hERG1 channels conduct rapid delayed rectifier K+ currents (IKr) in the human cardiac tissue. KCNH2 encodes 2 main isoforms—hERG1a and...

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Bibliographic Details
Main Authors: Li Feng, Kejuan Ma, Xin Li, Nian Liu, Deyong Long, Changsheng Ma
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2024-06-01
Series:Cardiology Discovery
Online Access:http://journals.lww.com/10.1097/CD9.0000000000000125
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http://journals.lww.com/10.1097/CD9.0000000000000125

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