Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i>

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i>

Dengue, West Nile, Zika, Yellow fever, and Japanese encephalitis viruses persist as significant global health threats. The development of new therapeutic strategies based on inhibiting essential viral enzymes or viral–host protein interactions is problematic due to the fast mutation rate and rapid e...

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Bibliographic Details
Main Authors: Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
Zika virus
protease inhibitors
mutation rates
allosteric druggable pockets
Dengue
Yellow Fever
Online Access:https://www.mdpi.com/1999-4915/17/1/6
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