Plasma microbial cell-free DNA characterization in different populations based on the droplet digital PCR method: a multi-cohort study

Plasma microbial cell-free DNA characterization in different populations based on the droplet digital PCR method: a multi-cohort study

BackgroundPlasma microbial cell-free DNA (mcfDNA) is a key biomarker for diagnosing bloodstream infections (BSIs), which contribute significantly to morbidity and mortality, particularly in patients with severe trauma, chronic illnesses, or immunosuppressive conditions. However, the baseline distrib...

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Main Authors: Juan Du, Dong Zhang, Fengliu Wang, Xuesong Shang, Jingjia Zhang, Guanhua Wang, Jingwen Ding, Aiwu Ren, Shuang Jing, Lu Bai, Ying Liu, Ye Zhao, Peng Li, Shuyi Yang, Jing Liu, Xuefang Xiang, Qiang Chen, Yingchun Xu, Jiang Xia, Qiwen Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
plasma microbial cell-free DNA
bloodstream infection
sepsis
pathogen
droplet digital PCR
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1578820/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1578820/full

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