The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice

The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice

Abstract Background Myeloid cells are heterogeneous cells that are critical for spontaneous choroidal neovascularization (CNV) in the Vldlr −/− mouse model. However, the specific myeloid cell subtype necessary for CNV remains unknown. Methods and results To investigate the role of monocytes, we bred...

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Bibliographic Details
Main Authors: Amrita Rajesh, Joyce Gong, Kyle S Chan, Ritvik Viniak, Steven Droho, David Kachar, Joshua Y Strauss, Andrew L. Wang, Jeremy A. Lavine
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
Angiogenesis
Choroidal neovascularization
Macrophage
Macular degeneration
Microglia
Vldlr
Online Access:https://doi.org/10.1186/s12974-025-03398-3
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https://doi.org/10.1186/s12974-025-03398-3

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