PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes

PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes

Background Diabetes mellitus (DM) is a chronic metabolic disease that poses serious threats to human physical and mental health worldwide. The PDZ domain-containing 8 (PDZD8) protein mediates mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) formation in mammals. We explored the role...

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Bibliographic Details
Main Authors: Yongxin Liu, Yongqing Wei, Xiaolong Jin, Hongyu Cai, Qianqian Chen, Xiujuan Zhang
Format: Article
Language:English
Published: Korean Diabetes Association 2024-11-01
Series:Diabetes & Metabolism Journal
Subjects:
diabetes mellitus
endoplasmic reticulum
mitochondria
pdzd8 protein, mouse
Online Access:http://e-dmj.org/upload/pdf/dmj-2023-0275.pdf
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http://e-dmj.org/upload/pdf/dmj-2023-0275.pdf

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