Through its genoprotective, mitochondrial bioenergetic modulation, and antioxidant effects, Fucoxanthin and its metabolite minimize Ochratoxin A-induced nephrotoxicity in HK-2 human kidney cells

Through its genoprotective, mitochondrial bioenergetic modulation, and antioxidant effects, Fucoxanthin and its metabolite minimize Ochratoxin A-induced nephrotoxicity in HK-2 human kidney cells

Abstract Background Ochratoxin A (OTA) is a mycotoxin with reported multiorgan toxicity, especially kidney toxicity. Fucoxanthin (FX) and its hydrolyzed metabolite Fucoxanthinol (FXL) have reno-protective antioxidant and anti-inflammatory properties. This study evaluates the nephroprotective effects...

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Main Authors: Ekramy M. Elmorsy, Huda A. Al Doghaither, Ayat B. Al-Ghafari, Shaza A. Alyamani, Zakariya M. S. Mohammed, Neven A. Ebrahim, Gehad E. Elshopakey, Sameh M. Shabana
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Nephrology
Subjects:
Fucoxanthin
Fucoxanthinol
Ochratoxin A
Nephrotoxicity
Oxidative stress
Mitochondria
Online Access:https://doi.org/10.1186/s12882-025-04276-z
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https://doi.org/10.1186/s12882-025-04276-z

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