Sequence signatures and mRNA concentration can explain two‐thirds of protein abundance variation in a human cell line

Sequence signatures and mRNA concentration can explain two‐thirds of protein abundance variation in a human cell line

Abstract Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global contributions to steady‐state protein concentrations in multi‐cellular eukaryotes are largely unknown. Using measurements of absolute protein a...

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Bibliographic Details
Main Authors: Christine Vogel, Raquel de Sousa Abreu, Daijin Ko, Shu‐Yun Le, Bruce A Shapiro, Suzanne C Burns, Devraj Sandhu, Daniel R Boutz, Edward M Marcotte, Luiz O Penalva
Format: Article
Language:English
Published: Springer Nature 2010-08-01
Series:Molecular Systems Biology
Subjects:
gene expression regulation
protein degradation
protein stability
translation
Online Access:https://doi.org/10.1038/msb.2010.59
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https://doi.org/10.1038/msb.2010.59

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