Repurposing of apoptotic inducer drugs against Mycobacterium tuberculosis

Repurposing of apoptotic inducer drugs against Mycobacterium tuberculosis

Abstract Computational approaches complement traditional in-vitro or in-vivo assays, significantly accelerating the drug discovery process by increasing the probability of identifying promising lead compounds. In this study, the apoptotic compounds were assessed for antimycobacterial activity and im...

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Main Authors: Kudakwashe Nyambo, Vivette Soko, Kudzanai Ian Tapfuma, Bongani Motaung, Francis Adu-Amankwaah, Lauren Julius, Ashwil Klein, Marshall Keyster, Lucinda Baatjies, Liezel Smith, Krishna Kuben Govender, Mkhuseli Ngxande, Andre G. Loxton, Vuyo Mavumengwana
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Drug repurposing
Tuberculosis
Host-directed therapy
Cytokine profiling
Molecular dynamics simulation
Online Access:https://doi.org/10.1038/s41598-025-91096-8
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https://doi.org/10.1038/s41598-025-91096-8

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