Association of plasma metabolites and cardiac mitochondrial function with heart failure progression

Association of plasma metabolites and cardiac mitochondrial function with heart failure progression

Abstract Aims Plasma metabolites are prognostic in heart failure with reduced ejection fraction (HFrEF), with citric acid cycle metabolites linked to ejection fraction (EF) changes. We investigated these mechanisms in a canine chronic HFrEF model. We tested associations between changes in plasma met...

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Main Authors: Vandana Revathi Venkateswaran, Ruicong She, Stephen J. Gardell, Jasmine A. Luzum, Ramesh Gupta, Kefei Zhang, L. Keoki Williams, Hani N. Sabbah, David E. Lanfear
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:ESC Heart Failure
Subjects:
cardiac mitochondrial progression
heart failure
plasma metabolite
plasma metabolomic profiling
Online Access:https://doi.org/10.1002/ehf2.15215
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https://doi.org/10.1002/ehf2.15215

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