Impact of Y chromosome loss on the risk of Parkinson's disease and progressionResearch in context

Impact of Y chromosome loss on the risk of Parkinson's disease and progressionResearch in context

Summary: Background: Loss of Y chromosome (LOY), an age-related somatic mutation, is associated with various age-related diseases, but its role in the onset and progression of Parkinson's disease (PD) remains unclear. This study investigated the relationship between blood LOY levels and the ri...

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Main Authors: Junhao Wang, Xinyi Chen, Wenxuan Du, Cha Lin, Yu Liao, Jean-Christophe Corvol, Jodi Maple-Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Michael A. Schwarzschild, Pille Taba, Sulev Kõks, Guido Alves, Ole-Bjørn Tysnes, Joel S. Perlmutter, Baijayanta Maiti, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Clemens R. Scherzer, Ganqiang Liu, Rebecca R. Valentino, Zhixiang Liao, Joseph J. Locascio, Xianjun Dong, Graziella Mangone, John H. Growdon, Albert Y. Hung, Michael A. Schwarzchild, Michael T. Hayes, Anne-Marie Wills, Todd M. Herrington, Bernard Ravian, Ira Shoulson, Thomas G. Beach, Florence Cormier-Dequaire, Peter Heutink, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Johan Marinus
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
Parkinson's disease
LOY
Onset
Progression
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002130
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http://www.sciencedirect.com/science/article/pii/S2352396425002130

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