A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression.

A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression.

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Necrotizing enterocolitis (NEC) is an inflammatory gastrointestinal process that afflicts approximately 10% of preterm infants born in the United States each year, with a mortality rate of 30%. NEC severity is graded using Bell's classification system, from stage I mild NEC to stage III severe...

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Main Authors: Cuilee Sha, Trevor Van Brunt, Jacob Kudria, Donna Schmidt, Alisa Yurovsky, Jela Bandovic, Michael Giarrizzo, Joyce Lin, Styliani-Anna Tsirka, Agnieszka B Bialkowska, Lonnie P Wollmuth, Esther M Speer, Helen Hsieh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0323626
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https://doi.org/10.1371/journal.pone.0323626

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