AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates

AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates

Abstract The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its activity and promote cell proliferation under nutrient stress conditions. W...

Full description

Saved in:
Bibliographic Details
Main Authors: William J. Smiles, Ashley J. Ovens, Dingyi Yu, Naomi X. Y. Ling, Andrea C. Poblete Goycoolea, Kaitlin R. Morrison, Emmanuel O. Murphy, Astrid Glaser, Sophie F. Monks O’Byrne, Scott Taylor, Alistair M. Chalk, Carl R. Walkley, Luke M. McAloon, John W. Scott, Bruce E. Kemp, Ashfaqul Hoque, Christopher G. Langendorf, Janni Petersen, Sandra Galic, Jonathan S. Oakhill
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Metabolic Health and Disease
Online Access:https://doi.org/10.1038/s44324-025-00052-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s44324-025-00052-7

Similar Items