Advanced lung adenocarcinoma harboring uncommon EGFR 19 Del and T790M/trans-C797S mutations after resistance: a case report and literature review

The most common epidermal growth factor receptor (EGFR) mutation in non-small cell lung cancer (NSCLC) is exon 19 deletion (19del), which is sensitive to EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, uncommon EGFR 19del mutations exhibit varied responses to EGFR-TKI treatment. Research and c...

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Bibliographic Details
Main Authors: Yuting Xiao, Dunqiang Ren, Huanhuan Bi, Yinxue Zhou, Yanmei Shao, Weizhong Han, Na Na, Hongmei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1525885/full
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