Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1
Abstract Reactivation of HIV gene expression in latently infected cells together with an efficient cART has been proposed as an adjuvant therapy aimed at eliminating/decreasing the reservoir size. Results from HIV clinical trials using deacetylase inhibitors (HDACIs) question the efficiency of these...
Saved in:
| Main Authors: | Sophie Bouchat, Nadège Delacourt, Anna Kula, Gilles Darcis, Benoit Van Driessche, Francis Corazza, Jean‐Stéphane Gatot, Adeline Melard, Caroline Vanhulle, Kabamba Kabeya, Marion Pardons, Véronique Avettand‐Fenoel, Nathan Clumeck, Stéphane De Wit, Olivier Rohr, Christine Rouzioux, Carine Van Lint |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2015-12-01
|
| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.201505557 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer
by: Therese Seidlitz, et al.
Published: (2022-08-01) -
5-aza-2′-deoxycytidine Inhibits the Proliferation of Lung Fibroblasts in Neonatal Rats Exposed to Hyperoxia
by: Shimeng Zhao, et al.
Published: (2017-04-01) -
Mechanisms of HDACs in cancer development
by: Ying Zhang, et al.
Published: (2025-04-01) -
Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects
by: Kiara E. Bornes, et al.
Published: (2025-01-01) -
Discovery and structural studies of histone demethylases
by: Longfei Peng, et al.
Published: (2025-05-01)