Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1

Abstract Reactivation of HIV gene expression in latently infected cells together with an efficient cART has been proposed as an adjuvant therapy aimed at eliminating/decreasing the reservoir size. Results from HIV clinical trials using deacetylase inhibitors (HDACIs) question the efficiency of these...

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Main Authors: Sophie Bouchat, Nadège Delacourt, Anna Kula, Gilles Darcis, Benoit Van Driessche, Francis Corazza, Jean‐Stéphane Gatot, Adeline Melard, Caroline Vanhulle, Kabamba Kabeya, Marion Pardons, Véronique Avettand‐Fenoel, Nathan Clumeck, Stéphane De Wit, Olivier Rohr, Christine Rouzioux, Carine Van Lint
Format: Article
Language:English
Published: Springer Nature 2015-12-01
Series:EMBO Molecular Medicine
Subjects:
demethylating agent
epigenetics
HDACIs
HIV latency
HIV reservoir
Online Access:https://doi.org/10.15252/emmm.201505557
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https://doi.org/10.15252/emmm.201505557

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