Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System

Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System

Protection of isolated pancreatic islets against hypoxic and oxidative damage-induced apoptosis is essential during a pretransplantation culture period. A beneficial approach to maintain viable and functional islets is the coculture period with mesenchymal stem cells (MSCs). Hypoxia preconditioning...

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Main Authors: Somayeh Keshtkar, Maryam Kaviani, Zahra Jabbarpour, Fatemeh Sabet Sarvestani, Mohammad Hossein Ghahremani, Elaheh Esfandiari, Mahdokht Hossein Aghdaei, Saman Nikeghbalian, Alireza Shamsaeefar, Bita Geramizadeh, Negar Azarpira
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2020/8857457
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http://dx.doi.org/10.1155/2020/8857457

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