The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

The TRIP12 E3 ligase induces SWI/SNF component BRG1-β-catenin interaction to promote Wnt signaling

Abstract SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes displace nucleosomes to promote the access of transcription factors to enhancers and promoters. Despite the critical roles of SWI/SNF in animal development and tumorigenesis, how signaling pathways recruit SWI/SNF compl...

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Main Authors: Sara Kassel, Kai Yuan, Nawat Bunnag, Leif R. Neitzel, Wenhui Lu, Anna Schwarzkopf, Benjamin Maines, Matthew A. Loberg, George Xu, Amber Adams, Andrew D. McCray, Alex Cho, Mary Rockouski, Gemma Orton, Lily Goldsmith, Md Mubtaseem Ahnaf Aronno, Zachary T. Spencer, Omar M. Khan, Fei Ye, Charles Williams, Andres M. Lebensohn, Rajat Rohatgi, Xiaofeng Wang, Vivian L. Weiss, Charles C. Hong, Arminja N. Kettenbach, David J. Robbins, Yashi Ahmed, Ethan Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60535-5
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https://doi.org/10.1038/s41467-025-60535-5

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