BubR1 Controls Heart Development by Promoting Expression of Cardiogenesis Regulators

BubR1 Controls Heart Development by Promoting Expression of Cardiogenesis Regulators

Background Congenital heart defects are structural anomalies present at birth that can affect the function of the heart. Aneuploidy is a significant risk factor for congenital heart defects. Mosaic variegated aneuploidy syndrome, caused by mutations in Bub1b (encoding BubR1, a mitotic checkpoint pro...

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Bibliographic Details
Main Authors: Renju Pun, Aradhana Thapa, Sylar R. Takafuji, Rexton M. Suzuki, Gabrielle F. Kay, Toni D. Howard, Michael H. Kim, Brian J. North
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
BubR1
cardiac development
congenital heart defects
MVA syndrome
single‐cell RNA sequencing
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.038286
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https://www.ahajournals.org/doi/10.1161/JAHA.124.038286

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