Expression profiles of miR-411 and SPRY4 as indicators of disease progression and treatment in chronic myelogenous leukemia

Expression profiles of miR-411 and SPRY4 as indicators of disease progression and treatment in chronic myelogenous leukemia

Abstract Chronic myeloid leukemia (CML) is a clonal neoplasm originating from hematopoietic stem cells which is characterized by t(9;22)(q34;q11.2) fusion gene leading to forming an oncoprotein. miR-411 and SPRY4 may influence CML leukemogenesis by regulating proliferation, differentiation, and vari...

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Bibliographic Details
Main Authors: Ashkan Shabannezhad, Nasrin Alizadghandforoush, Majid Safa, Shahrbano Rostami, Bahram Chahardouli, Ali Amini
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Chronic myelogenous leukemia
miR-411
SPRY4
Hematologic malignancies
Hematologic neoplasm
Gene expression
Online Access:https://doi.org/10.1038/s41598-025-13100-5
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https://doi.org/10.1038/s41598-025-13100-5

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