Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

Abstract Outbreaks of Bordetella pertussis (BP), the causative agent of whooping cough, continue despite broad vaccination coverage and have been increasing since vaccination switched from whole-BP (wP) to acellular BP (aP) vaccines. wP vaccination has been associated with more durable protective im...

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Bibliographic Details
Main Authors: Lisa Willemsen, Jiyeun Lee, Pramod Shinde, Ferran Soldevila, Minori Aoki, Shelby Orfield, Mari Kojima, Ricardo da Silva Antunes, Alessandro Sette, Bjoern Peters
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58460-8
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https://doi.org/10.1038/s41467-025-58460-8

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