Improving the drug delivery performance of ZIF-8 with amine functionalization as a 5-fluorouracil nanocarrier

Abstract This study investigates the effect of amine functional groups in ZIF-8 metal–organic frameworks on the loading and release of 5-fluorouracil (5-FU). The facile and cost-effective solvent-assisted linker exchange (SALE) method was used to exchange 2-methylimidazole (2-MIM) linkers with 3-ami...

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Bibliographic Details
Main Authors: Sahba Mirzanejad, Mojtaba Bagherzadeh, Arshad Bayrami, Hossein Daneshgar, Aida Bahrami, Majid Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-03542-2
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