SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity

Abstract SARS-CoV-2 hijacks multiple organelles for virion assembly, of which the mechanisms have not been fully understood. Here, we identified a SARS-CoV-2-driven membrane structure named the 3a dense body (3DB). 3DBs are unusual electron-dense and dynamic structures driven by the accessory protei...

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Bibliographic Details
Main Authors: Stella Hartmann, Lisa Radochonski, Chengjin Ye, Luis Martinez-Sobrido, Jueqi Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59475-x
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