Homoharringtonine Inhibits CVS-11 and Clinical Isolates of Rabies Virus In Vitro: Identified via High-Throughput Screening of an FDA-Approved Drug Library

Homoharringtonine Inhibits CVS-11 and Clinical Isolates of Rabies Virus In Vitro: Identified via High-Throughput Screening of an FDA-Approved Drug Library

Rabies, a viral encephalitis caused by rabies virus (RABV), is 100% fatal upon the onset of symptoms. Effective post-exposure prophylaxis (PEP) measures are available, but they are often difficult to access in low-income countries. WHO estimates about 59,000 deaths due to rabies globally, and the ma...

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Main Authors: Kalenahalli Rajappa Harisha, Varun Kailaje, Ravinder Reddy Kondreddi, Chandra Sekhar Gudla, Shraddha Singh, Sharada Ramakrishnaiah, Shrikrishna Isloor, Shridhar Narayanan, Radha Krishan Shandil, Gudepalya Renukaiah Rudramurthy
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Viruses
Subjects:
clinical isolate
CVS-11
flow cytometry
high-throughput assay
homoharringtonine
RABV
Online Access:https://www.mdpi.com/1999-4915/17/7/945
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