Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy
Enlarged perivascular spaces (PVS) in the centrum semiovale are an important marker of Cerebral Amyloid Angiopathy (CAA) and are thought to reflect brain clearance dysfunction. However, the current golden standard for assessing PVS is limited to a unilateral, single slice, qualitative analysis, whic...
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Elsevier
2025-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225000488 |
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| author | Manon R. Schipper Thijs W. van Harten Arie-Tjerk Razoux-Schultz Kanishk Kaushik Lydiane Hirschler Sabine Voigt Ingeborg Rasing Emma A. Koemans Rosemarie van Dort Reinier G.J. van der Zwet Sanne E. Schriemer Erik W. van Zwet Jeroen van der Grond Mark A. van Buchem Steven M. Greenberg Marieke J.H. Wermer Matthias J.P. van Osch Marianne A.A. van Walderveen Sanneke van Rooden |
| author_facet | Manon R. Schipper Thijs W. van Harten Arie-Tjerk Razoux-Schultz Kanishk Kaushik Lydiane Hirschler Sabine Voigt Ingeborg Rasing Emma A. Koemans Rosemarie van Dort Reinier G.J. van der Zwet Sanne E. Schriemer Erik W. van Zwet Jeroen van der Grond Mark A. van Buchem Steven M. Greenberg Marieke J.H. Wermer Matthias J.P. van Osch Marianne A.A. van Walderveen Sanneke van Rooden |
| author_sort | Manon R. Schipper |
| collection | DOAJ |
| description | Enlarged perivascular spaces (PVS) in the centrum semiovale are an important marker of Cerebral Amyloid Angiopathy (CAA) and are thought to reflect brain clearance dysfunction. However, the current golden standard for assessing PVS is limited to a unilateral, single slice, qualitative analysis, which has the disadvantage of a strong ceiling effect. We aim to introduce a whole-brain PVS volume fraction (PVSvf) measurement to assess cross-sectional and longitudinal PVSvf differences between pre-symptomatic and symptomatic Dutch-type CAA (D-CAA) mutation carriers and similar-age controls. PVSvf was assessed with a Frangi-vesselness filter-based, segmentation tool developed in-house and was compared cross-sectionally in 70 participants (28 symptomatic D-CAA, 17 pre-symptomatic D-CAA, 10 controls > 50 years, 17 controls ≤ 50 years) and longitudinally in 40 participants (16 symptomatic D-CAA, 13 pre-symptomatic D-CAA, 11 controls combined from both age groups). We found a higher baseline PVSvf in symptomatic D-CAA compared to controls ≤ 50 years (p < 0.0001, 95% CI [−0.051, −0.025]) and controls > 50 years (p < 0.0001, 95% CI [-0.042, −0.016]), in pre-symptomatic D-CAA compared to controls ≤ 50 years (p = 0.023, 95% CI [−0.035, −0.002]), and in controls > 50 years compared to controls ≤ 50 years (p < 0.001, 95% CI [0.004, 0.014]). We found no group differences in PVSvf change over time. The introduction of this quantitative measure of PVS volume in D-CAA showed cross-sectional differences already in pre-symptomatic D-CAA, indicating increased PVSvf in the early stages of D-CAA. We did not observe longitudinal differences over a four-year follow-up when analyzed at group level. |
| format | Article |
| id | doaj-art-da8d8cc7b4f948d3bbef5123542378af |
| institution | OA Journals |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | NeuroImage: Clinical |
| spelling | doaj-art-da8d8cc7b4f948d3bbef5123542378af2025-08-20T02:34:43ZengElsevierNeuroImage: Clinical2213-15822025-01-014610377810.1016/j.nicl.2025.103778Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid AngiopathyManon R. Schipper0Thijs W. van Harten1Arie-Tjerk Razoux-Schultz2Kanishk Kaushik3Lydiane Hirschler4Sabine Voigt5Ingeborg Rasing6Emma A. Koemans7Rosemarie van Dort8Reinier G.J. van der Zwet9Sanne E. Schriemer10Erik W. van Zwet11Jeroen van der Grond12Mark A. van Buchem13Steven M. Greenberg14Marieke J.H. Wermer15Matthias J.P. van Osch16Marianne A.A. van Walderveen17Sanneke van Rooden18Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Corresponding author at: Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.Department of Radiology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Neurology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Biostatistics, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsHemorrhagic Stroke Research Program, J Philip Kistler Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA, USADepartment of Neurology, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, University Medical Center Groningen, Groningen, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, Leiden, the NetherlandsEnlarged perivascular spaces (PVS) in the centrum semiovale are an important marker of Cerebral Amyloid Angiopathy (CAA) and are thought to reflect brain clearance dysfunction. However, the current golden standard for assessing PVS is limited to a unilateral, single slice, qualitative analysis, which has the disadvantage of a strong ceiling effect. We aim to introduce a whole-brain PVS volume fraction (PVSvf) measurement to assess cross-sectional and longitudinal PVSvf differences between pre-symptomatic and symptomatic Dutch-type CAA (D-CAA) mutation carriers and similar-age controls. PVSvf was assessed with a Frangi-vesselness filter-based, segmentation tool developed in-house and was compared cross-sectionally in 70 participants (28 symptomatic D-CAA, 17 pre-symptomatic D-CAA, 10 controls > 50 years, 17 controls ≤ 50 years) and longitudinally in 40 participants (16 symptomatic D-CAA, 13 pre-symptomatic D-CAA, 11 controls combined from both age groups). We found a higher baseline PVSvf in symptomatic D-CAA compared to controls ≤ 50 years (p < 0.0001, 95% CI [−0.051, −0.025]) and controls > 50 years (p < 0.0001, 95% CI [-0.042, −0.016]), in pre-symptomatic D-CAA compared to controls ≤ 50 years (p = 0.023, 95% CI [−0.035, −0.002]), and in controls > 50 years compared to controls ≤ 50 years (p < 0.001, 95% CI [0.004, 0.014]). We found no group differences in PVSvf change over time. The introduction of this quantitative measure of PVS volume in D-CAA showed cross-sectional differences already in pre-symptomatic D-CAA, indicating increased PVSvf in the early stages of D-CAA. We did not observe longitudinal differences over a four-year follow-up when analyzed at group level.http://www.sciencedirect.com/science/article/pii/S2213158225000488Perivascular spacesBrain clearanceAmyloid-βCerebral amyloid angiopathyDutch-type cerebral amyloid angiopathyHereditary cerebral hemorrhage with amyloidosis Dutch-type |
| spellingShingle | Manon R. Schipper Thijs W. van Harten Arie-Tjerk Razoux-Schultz Kanishk Kaushik Lydiane Hirschler Sabine Voigt Ingeborg Rasing Emma A. Koemans Rosemarie van Dort Reinier G.J. van der Zwet Sanne E. Schriemer Erik W. van Zwet Jeroen van der Grond Mark A. van Buchem Steven M. Greenberg Marieke J.H. Wermer Matthias J.P. van Osch Marianne A.A. van Walderveen Sanneke van Rooden Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy NeuroImage: Clinical Perivascular spaces Brain clearance Amyloid-β Cerebral amyloid angiopathy Dutch-type cerebral amyloid angiopathy Hereditary cerebral hemorrhage with amyloidosis Dutch-type |
| title | Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy |
| title_full | Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy |
| title_fullStr | Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy |
| title_full_unstemmed | Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy |
| title_short | Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy |
| title_sort | cross sectional and longitudinal quantification of total white matter perivascular space volume fraction in dutch type cerebral amyloid angiopathy |
| topic | Perivascular spaces Brain clearance Amyloid-β Cerebral amyloid angiopathy Dutch-type cerebral amyloid angiopathy Hereditary cerebral hemorrhage with amyloidosis Dutch-type |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225000488 |
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