mPFC DCC coupling with CaMKII+ neuronal excitation participates in behavioral despair in male mice

Abstract A longed lack of control over harmful stimuli can lead to learned helplessness (LH), a significant factor in depression. However, the cellular and molecular mechanisms underlying LH, and eventually behavioral despair, remain largely unknown. The deleted in colorectal cancer (dcc) gene is as...

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Bibliographic Details
Main Authors: Ping Cheng, Keke Ding, Daokang Chen, Chen Yang, Juan Wang, Shaojie Yang, Ming Chen, Guoqi Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2025-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03266-x
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