Hymecromone Promotes Longevity and Insulin Sensitivity in Mice

Hymecromone Promotes Longevity and Insulin Sensitivity in Mice

Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. We designed a prospective study of long-term administration of 4-MU with conventional C57BL/6J mice. We...

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Main Authors: Nadine Nagy, Kathryn S. Czepiel, Gernot Kaber, Darko Stefanovski, Aviv Hargil, Nina Pennetzdorfer, Robert Targ, Saranya C. Reghupaty, Thomas N. Wight, Robert B. Vernon, Rebecca L. Hull-Meichle, Payton Marshall, Carlos O. Medina, Hunter Martinez, Anissa Kalinowski, Rudolph D. Paladini, Stavros Garantziotis, Joshua W. Knowles, Paul L. Bollyky
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
hymecromone
longevity
insulin resistance
glycemic control
hyaluronan
Online Access:https://www.mdpi.com/2073-4409/13/20/1727
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https://www.mdpi.com/2073-4409/13/20/1727

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