EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors

EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors

Abstract Glioblastoma (GBM) is a typically lethal type of brain tumor with a median survival of 15 months postdiagnosis. This negative prognosis prompted the exploration of alternative treatment options. In particular, the reliance of GBM on angiogenesis triggered the development of anti‐VEGF (vascu...

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Main Authors: Nevenka Dudvarski Stanković, Frank Bicker, Stefanie Keller, David TW Jones, Patrick N Harter, Arne Kienzle, Clarissa Gillmann, Philipp Arnold, Anna Golebiewska, Olivier Keunen, Alf Giese, Andreas von Deimling, Tobias Bäuerle, Simone P Niclou, Michel Mittelbronn, Weilan Ye, Stefan M Pfister, Mirko HH Schmidt
Format: Article
Language:English
Published: Springer Nature 2018-08-01
Series:EMBO Molecular Medicine
Subjects:
angiogenesis
EGFL7
endothelial cell
glioblastoma
integrin
Online Access:https://doi.org/10.15252/emmm.201708420
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https://doi.org/10.15252/emmm.201708420

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