Competitive binding of actin and SH3 domains at proline-rich regions of Las17/WASP regulates actin polymerisation

Abstract Eukaryotic actin filaments bind factors that regulate their assembly and disassembly creating a self-organising system, the actin cytoskeleton. Despite extensive knowledge of signals that modulate actin organisation, significant gaps remain in our understanding of spatiotemporal regulation...

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Bibliographic Details
Main Authors: Lewis P. Hancock, John S. Palmer, Ellen G. Allwood, Iwona I. Smaczynska-de Rooij, Anthony J. Hodder, Michelle L. Rowe, Mike P. Williamson, Kathryn R. Ayscough
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08188-4
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