The microbial metabolite imidazole propionate dysregulates bone homeostasis by inhibiting AMP-activated protein kinase (AMPK) signaling

The microbial metabolite imidazole propionate dysregulates bone homeostasis by inhibiting AMP-activated protein kinase (AMPK) signaling

Abstract Microbial metabolites provide numerous benefits to the human body but can also contribute to diseases such as obesity, diabetes, cancer, and bone disorders. However, the role of imidazole propionate (ImP), a histidine-derived metabolite produced by the intestinal microbiome, in bone metabol...

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Main Authors: Suk-Gyun Park, Jung-Woo Kim, Ju Han Song, Seung-Hee Kwon, Sin-Hye Oh, Xianyu Piao, Zhao Wang, Je-Hwang Ryu, Nacksung Kim, Ok-Su Kim, Jeong-Tae Koh
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07316-w
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https://doi.org/10.1038/s42003-024-07316-w

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