Humanized mouse models of KRAS-mutated colorectal and pancreatic cancers with HLA-class-I match for pre-clinical evaluation of cancer immunotherapies

Humanized mouse models of KRAS-mutated colorectal and pancreatic cancers with HLA-class-I match for pre-clinical evaluation of cancer immunotherapies

Cancer immunotherapy promises to treat challenging cancers including KRAS-mutated colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). However, pre-clinical animal models that better mimic patient tumor and immune system interactions are required. While humanized mice are promising v...

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Bibliographic Details
Main Authors: Maria E. Davola, Olga Cormier, Madeleine Lepard, Jamie McNicol, Susan Collins, Joanne A. Hammill, Christopher Silvestri, Jonathan L. Bramson, Amy Gillgrass, Karen L. Mossman
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Cancer immunotherapy
colorectal cancer
HLA class I match
HLA-A2.1
humanized cancer model
humanized mice
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2473163
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2473163

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